Allosteric modulation of caspase 3 through mutagenesis
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چکیده
منابع مشابه
Allosteric modulation of caspase 3 through mutagenesis
A mutation in the allosteric site of the caspase 3 dimer interface of Val266 to histidine abolishes activity of the enzyme, and models predict that the mutation mimics the action of small molecule allosteric inhibitors by preventing formation of the active site. Mutations were coupled to His266 at two sites in the interface, E124A and Y197C. We present results from X-ray crystallography, enzyma...
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ژورنال
عنوان ژورنال: Bioscience Reports
سال: 2012
ISSN: 0144-8463,1573-4935
DOI: 10.1042/bsr20120037